A large amount of prolonged use may cause hypercalcemia, loss of appetite, vomiting, diarrhea and even heterotopic ossification of soft tissues. Overdose, such as 100,000~200,000 units per day for adults and 20,000~30,000 units per day for children, can be toxic for weeks or months, with symptoms of anorexia, fatigue, weakness, nausea, vomiting, diarrhea, polyuria, profuse sweating, headache and thirst. Increased calcium and phosphorus concentrations in serum and urine can lead to hypertension and renal failure. If any of the above conditions occur, you need to go to the hospital in time and under the guidance of your doctor.