Sleepy legs generally refers to leg weakness, there is no such thing as what is the most effective medicine for leg weakness. Leg weakness may be caused by calcium deficiency, hypokalemia, and atherosclerotic occlusive disease of the lower limbs, which requires calcium, potassium, and antiplatelet aggregation drugs such as calcium gluconate, potassium chloride, and aspirin. Patients with calcium deficiency will have weakness, hand and foot twitching and other manifestations. Patients can use calcium agents such as calcium gluconate and calcium citrate under the guidance of the doctor. If the weakness of legs is caused by hypokalemia, potassium chloride, potassium citrate and other potassium agents should be used under medical advice. In addition, patients with lower limb atherosclerotic occlusive disease will also manifest as leg weakness, and patients can use antiplatelet aggregation drugs, such as aspirin, clopidogrel, etc. under the guidance of the doctor. Patients with cerebral infarction, lumbar disc herniation can also lead to leg weakness. It is recommended that patients with leg weakness need to consult a doctor in a timely manner, the doctor will choose the appropriate medication according to the cause of the disease, the patient needs to comply with the doctor’s instructions to use medication, can not be unauthorized use of medication.