Leakage of amniotic fluid is usually detected within 24 hours after amniocentesis and requires prompt hospitalization. Amniocentesis, or amniocentesis, is one of the methods of prenatal diagnosis and is used to screen the fetus for risks of chromosomal disorders and genetic diseases, etc. It has to be performed by a specialized physician when the pregnancy is in the 16th to 22nd week of gestation. Strict asepsis should be practiced during amniocentesis to prevent infection. The puncture should be performed under the guidance of ultrasound and the position of the placenta should be clarified. During puncture, care should be taken to avoid damaging the placenta. During puncture and before and after needle removal, attention should also be paid to whether the pregnant woman has any abnormalities such as dyspnea and suffocation, so as to be alert to the occurrence of amniotic fluid embolism; the puncture site should be secured by pressure with aseptic dry gauze after the operation, so as to avoid the leakage of amniotic fluid. Because amniocentesis is an invasive operation, there is a risk of amniotic fluid leakage, the incidence rate of 1%-2%, usually occurring within 24 hours after the amniocentesis, but also close observation after the operation.