Waking up at two or three o’clock may be caused by psychological disorders, sleep-wake rhythm disorders, other diseases, etc. If it is a pathological factor, it is necessary to consult a doctor for targeted treatment. 1. Mental illness: anxiety, depression and other mental illnesses can cause people with the disease to have their sleep affected, with clinical manifestations such as difficulty in falling asleep, easy to wake up in the middle of the night, and shallow sleep. In this case, it is necessary to go to the psychiatry department of the hospital to relieve the related bad moods through the doctor’s guidance. 2. Sleep-wake rhythm disorders: Some elderly people have changes in their sleep rhythm due to ageing, with relatively shorter and lighter sleep duration, which makes them prone to waking up in the early hours of the morning. In this case, you need to adjust your routine to avoid going to sleep too early. 3. Other diseases: clinically common diseases such as hyperthyroidism, which can cause the sick people’s metabolism in an abnormal state and sympathetic nerve in the state of excitation, clinical manifestations of palpitations, sweating, waking up in the middle of the night and so on. Early awakening needs to go to the hospital for timely consultation and correct treatment after diagnosis.