Enlarged and mobile submandibular lymph nodes are a description of the condition of submandibular lymph nodes in clinical examination, and the corresponding condition belongs to inflammatory lymph nodes or tumors, as well as some rare diseases. 1. Inflammatory lymph nodes: recent bacterial, viral infections, pathogen stimulation of lymph nodes, can cause submandibular lymph node enlargement, mobility can indicate that the surrounding inflammatory reaction is not obvious, there is no obvious adhesion. 2. Tumor: submandibular lymph node metastasis will also appear corresponding changes in the lymph node metastasis, with the increase in cell density will lead to lymph node enlargement, and spherical changes, and later will be accompanied by the disappearance of the lymph node door, the dermo-medullary demarcation is not uniform. In some rare diseases, such as tuberculosis and AIDS, submandibular lymph nodes may be enlarged and mobile. If the pain around the lymph node increases or even breaks down, it is necessary to observe it in time and standardize the treatment under the guidance of the clinician.