Chronic kidney disease stage IV may be restored to stage III with active and effective treatment. Generally, chronic kidney disease is a gradual progression, once the chronic kidney disease stage IV is reached, that is, the endogenous creatinine clearance is only between 15 and 29 ml/min, at this time, the kidneys lose most of the detoxification function, which then leads to toxins as well as water accumulation in the organism, causing organism poisoning as well as edema symptoms. The appearance of chronic kidney disease stage IV is caused by chronic kidney disease affected by a variety of suspicious factors, such as infection, bleeding and dehydration, and electrolyte disorders and taking nephrotoxic drugs (Guanmutong, ibuprofen), resulting in the deterioration of renal function caused by the removal of the causative factors, the fourth stage of renal disease may be restored to the third stage of the lesion. Chronic kidney disease is a relatively difficult disease to treat, so after diagnosis, patients need to actively regular hospitals, follow the doctor’s instructions for treatment, so as not to miss the condition.