Creutzfeldt-Jakob disease refers to Creutzfeldt-Jakob disease, which is different from syphilis in terms of pathogenesis, clinical features and treatment. 1. Pathogenesis: the specific cause of Creutzfeldt-Jakob disease, there is no definite conclusion, the disease has a lot to do with prion infection. Syphilis is mainly caused by syphilis spirochetes entering the human body through sexual contact, mother-to-child transmission, blood transmission and other ways. 2. Clinical features: The initial symptoms of Creutzfeldt-Jakob disease are not typical, and as the disease progresses, symptoms such as mental retardation, dementia, imbalance, myoclonus, tremor and so on will appear. The first stage of syphilis is characterized by a hard chancre and enlarged lymph nodes, while the second stage is characterized by a syphilitic rash, which can lead to the formation of syphilitic tumours and damage to cardiovascular vessels, bones, and skin and mucous membranes. 3. Treatment: Currently there is no effective treatment for Creutzfeldt-Jakob disease and drugs, more symptomatic treatment. Syphilis can be treated with penicillin drugs. Early syphilis is possible to cure, patients need to follow the doctor’s advice and actively cooperate with the treatment. Although there is no cure for Creutzfeldt-Jakob disease, early treatment can prolong the patient’s life.