The main symptom of coronary artery disease is chest tightness and chest pain, which is mainly caused by myocardial ischemia, so drugs that improve myocardial ischemia can reduce the symptoms, mainly including beta-blockers, nitrates and calcium channel blockers. β-blockers: β-blockers can slow down the heart rate, weaken myocardial contraction, lower blood pressure, reduce myocardial oxygen consumption and angina attacks. There are several beta-blockers available for the treatment of angina pectoris, all of which can effectively prevent angina attacks when given in adequate doses. Currently, the clinical preference is for selective β1-blockers, such as metoprolol, atenolol and bisoprolol. However, beta-blockers are contraindicated in patients with severe bradycardia and high atrioventricular block, sinus node dysfunction, significant bronchospasm or bronchial asthma. Nitrates: Nitrates can dilate blood vessels, reduce myocardial oxygen consumption, improve myocardial perfusion, and relieve angina symptoms. Sublingual or aerosol nitroglycerin can be used as a symptom reliever during an angina attack or minutes before exercise to reduce or avoid an angina attack. Long-acting nitrate drugs are used to reduce the frequency and degree of angina attacks and are suitable for chronic long-term treatment, such as isosorbide 5-mononitrate and isosorbide mononitrate extended-release preparations. Calcium channel blockers: play a role in relieving angina by improving coronary blood flow and reducing myocardial oxygen consumption. They can be divided into dihydropyridines and non-dihydropyridines. Dihydropyridines are commonly used in clinical practice, such as amlodipine and nifedipine, while non-dihydropyridines are commonly used in clinical practice, such as diltiazem. and verapamil. Calcium channel blockers are the first-line treatment for variant angina pectoris or angina pectoris with coronary artery spasm. Diltiazem? and verapamil slow down atrioventricular conduction and are often used in patients with angina pectoris with atrial fibrillation or atrial flutter. However, these two drugs should not be used in patients with severe bradycardia, high atrioventricular block, or sick sinus node syndrome.