Herpes zoster is a unilateral, striated, nerve fiber rash characterized by clusters of blisters and erythema with pain. The rash is usually preceded by mild fever, fatigue, general malaise, loss of appetite, and a burning sensation or neuralgia in the affected skin. After 1-3 days, erythema occurs in certain nerve distribution areas (commonly on the chest, waist, abdomen, face, etc.), followed by the appearance of numerous clusters of corn to green bean-sized papules, which rapidly turn into blisters with clear and clear contents and shiny, tense walls, and neuralgia. The pain is paroxysmal, pins and needles, burning, or tenderness, and sometimes the neuralgia may continue for days, months, or even years (especially in frail elderly people) until the rash subsides. The older you are, the more severe the pain. Prevention of shingles is not timely, and patients should generally seek medical attention as soon as possible after the occurrence of shingles, the earlier the treatment, the easier it is to cure; conversely, the condition will worsen, the pain will increase, and the milder the person will have residual neuralgia, the heavier the accident. Herpes zoster occurs in the intercostal nerve, cervical nerve, trigeminal nerve and lumbosacral nerve innervation areas in that order. The affected area often first appears as a flushed spot, followed by corn- to soybean-sized papules, which are distributed in clusters without fusion, and then rapidly turn into blisters with tense, shiny walls and clarified fluid, surrounded by a red halo, with normal skin between clusters of blisters; the lesions are arranged in a band along a peripheral nerve, mostly on one side of the body, and generally do not exceed the midline. If herpes zoster appears on the face, it can lead to headaches, facial paralysis, and even encephalitis. If herpes zoster appears around the orbits, it can lead to corneal invasion, resulting in corneal ulcers, viral uveitis, and in severe cases, even blindness. Ocular herpes zoster: Etiology: Herpes zoster is caused by varicella and herpes zoster viruses. The virus is latent in the nerve cells after the body’s initial infection. When the body’s immunity decreases, the virus is reactivated and proliferates along the sensory nerve fibers down to an area of the skin, where herpes zoster occurs, most commonly around the orbit. When the eye is involved, it causes conjunctivitis, sclerenitis, keratitis, iridocyclitis, retinitis and retinal necrosis. It causes acute retinal necrosis syndrome, which is a serious blinding eye disease. Clinical manifestations: Ocular lesions caused by herpes zoster are often accompanied by significant eye redness, eye pain, photophobia and tearing, and even severe vision loss. Corneal lesions present in a variety of ways. In the early stages, within a few days after the appearance of the rash, it can manifest as superficial coarse punctate keratitis. Uveitis due to herpes zoster can manifest as transient iritis, or severe iridocyclitis, chorioretinitis, acute retinal necrosis, retinal vasculitis, optic neuritis, and total uveitis. Severe corneal ulceration or secondary infection can lead to blindness, and uveitis, if left untreated, can lead not only to blindness but also to atrophy of the eye. Treatment: In addition to continuing systemic antiviral therapy after the development of an ocular lesion, targeted treatment should be given to address the characteristics of the ocular lesion. For example, for superficial punctate keratitis and pseudodendritic keratitis, antiviral drug drops can be used, but the efficacy is not yet certain. When corneal ulcers develop, care should be taken to protect the ocular surface with preservative-free artificial tears to promote ulcer healing and prevent secondary infection. Hormonal eye drops should be used when discoid keratoconjunctivitis is present. The most common treatments for iridocyclitis are hormonal eye drops, nonsteroidal anti-inflammatory drugs, and dilating eye drops. When posterior uveitis occurs, such as chorioretinitis, acute retinal necrosis, retinal vasculitis, optic neuritis, and total uveitis, appropriate systemic hormone therapy is used in conjunction with systemic antiviral medications to prevent permanent and severe visual impairment. Herpes zoster is a serious health hazard. Therefore, if symptoms of herpes zoster appear, you should promptly visit a hospital for antiviral treatment and, if accompanied by neuralgia, you should also visit an analgesic unit for appropriate medication and physical therapy to avoid posterior neuralgia. If eye pain and vision loss occur, you should visit an ophthalmologist as soon as possible to treat keratitis and uveitis to prevent blindness.