The concept of postherpetic neuralgia is defined by the American Academy of neurology (PHN) as postherpetic neuralgia when local pain persists for more than 3 months after the lesions of herpes zoster have subsided. The incidence of postherpetic neuralgia is particularly high in elderly patients over the age of 60 years, with an incidence of 50% to 75%. Once a patient develops postherpetic neuralgia, the patient’s pain lasts for a long time, ranging from a few months to several years or even a decade, causing great physical and psychological pain that not only hinders the patient’s social activities during the day, but also causes insomnia, loss of appetite, and even the development of depression. The longest patient we have seen is 11 years old, suffering from pain and seeking medical help. Nerve blocks are very effective in the early stages of herpes zoster (HZ) radiculitis, not only in reducing pain, but also in preventing postherpetic neuralgia (PHN). This approach has been widely recognized and adopted. Once a patient develops postherpetic neuralgia, however, the receiving physician often believes that the optimal time for nerve block has been lost and no longer treats the patient with a nerve block. Clinicians have a difficult time treating intractable postherpetic neuralgia and are searching for a definitive and effective analgesic method. In our pain clinic, 60 patients with intractable postherpetic neuralgia were treated with oral carbamazepine and doxepin along with nerve block, and good results were achieved with a VAS score of 3 or less, and they were able to live a normal life with a stable outcome and continued efficacy for six months of follow-up. The combination of nerve block with oral medication for treatment of intractable postherpetic neuralgia has strong analgesic effect, long maintenance time and lasting effect, which is worthy of clinical recommendation.