Patients with shingles may present with headaches, which are spontaneous symptoms that occur when the varicella-zoster virus involves the nerve roots of the head and face, usually in the form of paroxysmal tingling or burning, dull pains. In addition, even if shingles does not occur on the head and face, patients may experience malaise, headache, fever, and other discomfort due to the viral infection. Patients with shingles also experience pain during the rash, not only in the head, but also in the ear, eyes, and the whole body, which can be dull, jerking, or throbbing pain. The pain is usually paroxysmal and can sometimes be constant, and can be exacerbated by clothing contact or friction, and is more pronounced in older and frail patients. Therefore, having shingles should be treated as early as possible, with antiviral drugs preferred for treatment, such as acyclovir and valacyclovir. Since varicella-zoster virus can damage nerves, a combination of nerve-nourishing drugs, such as methylcobalamin, vitamin B1 and vitamin B12, is also needed. If the headache is obvious, pain medications such as indomethacin, carbamazepine, morphine, etc. can be used as prescribed by the doctor.