Tiotropium bromide is a commonly used anticholinergic drug for respiratory allergic diseases, mainly for bronchial asthma and chronic obstructive pulmonary disease. Depending on the classification and severity of asthma and COPD, the drug is used for a relatively long time, around 1-3 years. If the disease is effectively controlled, whether the drug can be stopped in between still depends on the patient’s lung function status and whether it is combined with other diseases, such as allergic rhinitis, diabetes, hypertension, coronary heart disease, etc. Because the more underlying diseases, the more difficult it is to control and the more difficult and shorter the time of temporary remission, it is not recommended to discontinue tiotropium bromide in between. If the patient is young, the history of chronic obstructive pulmonary disease and asthma is not long, has quit smoking, enhanced exercise, and has better ambient air, tiotropium bromide can be discontinued and replaced by other montelukast sodium, epalrestine alternative therapy, or Chinese herbal medicine can be chosen. Tiotropium bromide is mainly used in patients with bronchial asthma and chronic obstructive pulmonary disease who are insensitive to β2 agonists, and whether it can be discontinued is mainly based on the underlying condition and the patient’s other medications.