Small white pustules at the corners of the mouth are considered to be related to folliculitis, acne, boils and other factors, and can be treated with topical medication, daily care and oral medication. 1. Folliculitis: If the patient does not pay attention to local hygiene, it will lead to bacterial growth, which will stimulate the hair follicles, triggering folliculitis, leading to the symptom of small white pustules at the corner of the mouth. Patients can follow the doctor’s instructions to use erythromycin ointment, mupirocin ointment, etc. for treatment, which can play the role of anti-inflammatory and sterilization. 2. Acne: Hormonal disorders in the body stimulate the sebaceous glands to produce a large amount of oil, when the oil clogs the pores, it will trigger acne, and there are symptoms of long white pustules at the corners of the mouth. In daily life, patients can use mild and non-irritating cleanser to clean the local area, and if necessary, can follow the doctor’s instructions to apply topical retinoic acid cream, benzoyl peroxide and other medications to treat. 3. Boils: usually caused by acute suppurative inflammation of individual hair follicles or surrounding tissues. When the inflammation in the local repeated irritation will form boils, resulting in small white pustules at the corners of the mouth. Patients can be treated with antibiotic medications such as cefixime and amoxicillin as prescribed by the doctor. Small white pustules growing at the corners of the mouth may also have other causes, it is recommended to consult a doctor in time, cooperate with the doctor to carry out examinations to determine the cause and then treat the cause. The above medications should be used in strict compliance with the doctor’s instructions.