High anion gap is generally seen in metabolic acidosis, diabetic ketoacidosis, uremia, etc., should be directed at the cause of the treatment, and at the same time with dietary treatment, low salt, low carbohydrate, low fat diet. 1. Metabolic acidosis: due to acid-base metabolism disorders, should be active in the treatment of etiology, correction of acidosis, such as hypovolemia caused by rehydration, blood transfusion and other treatments. 2. Diabetic ketoacidosis: treatment to remove the causes (such as infection, etc.), supplemental saline, intravenous insulin, potassium supplementation. 3. Uremia: it can cause metabolic acidosis and needs to be treated by dialysis therapy. In the etiology of treatment at the same time should be accompanied by dietary therapy, such as moderate intake of chicken, beef and other protein-rich foods, may be appropriate to eat vegetables and fruits (cabbage, grapes, etc.), avoid eating high-sugar, high-fat, high cholesterol food (fruit juice, chocolate, fat meat, etc.), the diet should be low-salt, low-carbohydrate, low-fat, etc., but also need to drink more water. There may be other reasons for high anion gap, it is recommended to go to the hospital in time to identify the cause of the disease and then targeted treatment.