Rib irregularity at perforation site after minimally invasive surgery for esophageal cancer is particularly complicated, and its causes are related to fracture, metastasis of cancer, etc. In this case, therapeutic drugs should be chosen according to the condition of the patient, and if necessary, surgery should be performed again. 1. Fracture: after minimally invasive surgery for esophageal cancer, fracture is often caused by improper treatment or accident, which leads to irregularity of ribs at perforation site. In this case, patients can be given medication, and medication such as Bone-setting Tablets and Blood-activating Pain Relieving Capsules can be chosen according to doctor’s instruction, which can reduce pain and promote recovery of ribs’ morphology. 2. Cancer metastasis: Considering the high recurrence rate of esophageal cancer and the existence of metastasis, when the ribs in the perforated area are irregular, it is necessary to guard against cancer metastasis, which needs to be examined carefully, and once diagnosed, patients can be considered to undergo purging surgery again, and cooperate with the targeted nursing work after surgery. After minimally invasive surgery for esophageal cancer, the irregularity of ribs at the perforation site should go to the hospital in time to clarify the cause of the disease, and then the doctor will carry out corresponding treatment according to the patient’s condition.