Hand blisters are very itchy after hand skin cracking may be caused by contact dermatitis, sweat herpes, fungal infections, etc., need to be treated for the cause of the disease, generally based on drug treatment. 1. Contact dermatitis: contact dermatitis may occur due to contact with allergens or contact with soap, detergents and other chemicals, so blisters are very itchy hands after hand skin cracking. It can be treated with medications such as compound dexamethasone ointment and dianabed ointment. 2. Sweat herpes: due to the sweat glands in the hand to secrete too much sweat, resulting in sweat discharge is not smooth, stimulate the skin to trigger sweat herpes, can appear after the hand blisters very itchy hand skin cracking situation. You can take cetirizine tablets, loratadine and other drugs, can also be used externally mometasone furoate cream, glycerite lotion and other drugs. 3. Fungal infections: Fungal infections of the hands are caused by not paying attention to hand hygiene and cleanliness, and being in a humid environment for a long time. You can take itraconazole capsules, terbinafine tablets and other drugs, or topical miconazole ointment and other drugs. It is recommended that the patient go to the hospital in time to clarify the cause of the disease, and follow the doctor’s instructions to standardize the treatment.