When the symptoms of leg pain appear after a brain infarction, the infarction site is considered to be in the thalamus. Because the thalamus is the sensory nerve fiber center of the human body, when thalamic infarction occurs, patients will not only show symptoms such as numbness of the limbs, but also pain in the limbs, and anxiety and depression may develop after thalamic infarction. It is also possible that cerebral infarction leads to impaired leg movement, low leg movement or local venous thrombosis related. Symptoms of leg pain after cerebral infarction should be treated actively for cerebral infarction, and thrombolytic therapy can be considered if it is given within the time window of thrombolysis. If the time window of thrombolysis is missed, active treatment should also be given, and different options such as fibrin-lowering, anticoagulation, and antiplatelet aggregation can be chosen. At the same time, treatment such as oxygen radical scavenging and cerebral protection must be given to reduce the degree of brain nerve function damage, which is very necessary for the recovery of leg pain in the later stage. The acute phase of cerebral infarction should also control blood pressure, blood lipids and blood sugar for comprehensive treatment.