40 years old memory is very poor forgetfulness serious causes of overwork, physical disease, mental illness, can be treated by improving lifestyle, medication, psychotherapy and so on. 1. Overwork: This can happen if you have been under a lot of stress lately, using your brain too much, or staying up late for a long time. You can relax your brain and improve your symptoms by improving your lifestyle, ensuring enough sleep, and participating in more outdoor sports. 2. Physical diseases: such as memory loss caused by cerebrovascular disease, you can take aspirin, atorvastatin, cytarabine and other drugs for symptomatic treatment; caused by Alzheimer’s disease, you can take donepezil, megadonium, glycopyrrolate sodium and other drugs for symptomatic treatment. 3. Mental illness: depression, anxiety, insomnia, etc. can cause brain nerve dysfunction, causing memory problems, you can take drugs, psychotherapy and other methods to improve. Commonly used drugs are sertraline, venlafaxine, oxazepam and so on. There are many causes of memory loss, it is recommended that timely medical examination, clear cause targeted treatment, do not blindly self-medication.