Frequent dry and itchy throat at night can be clinically associated with the following diseases. The first disease species, chronic pharyngitis, of which allergic pharyngitis is more common. It may be that at night, the patient has a slight allergy to the air in the house, dust on the bed sheets and linens. When inhaled through the oropharynx, it causes the patient to experience discomfort in the throat, manifested as dry itching, along with a dry cough and other clinical manifestations. second disease, the patient may have reflux pharyngitis. At night, for example, when sleeping flat in bed after eating, it is easy to cause acid reflux in the gastroesophagus, which stimulates the mucous membrane of the throat and leads to the symptoms of reflux laryngitis. The clinical symptoms are mostly localized dryness and itching of the throat, cough, foreign body sensation in the throat, and dryness of the throat. In the third disease, some patients have tracheal and pulmonary disease, which leads to dry itching in patients. In this clinical condition, the patient may also have a cough and coughing sputum. In conclusion, for patients with dry itch at night, it is recommended that patients go to ENT and related departments such as respiratory medicine and gastroenterology for systematic examination.