Hypoechoic thyroid nodule with clear border is a kind of lesion that occurs in the thyroid gland. Although the nodule has a high possibility of being benign, it needs to be combined with other indications as well as laboratory tests and clinical symptoms to make a comprehensive judgment. Thyroid nodules are usually detected during ultrasound examination of the neck. Signs such as complete and clear boundaries, regular shape of the nodule, and homogeneous internal echoes suggest that the nodule is likely to be benign, and is usually caused by calcification, hematoma, or space occupation in the thyroid gland. Thyroid nodules need to be combined with laboratory tests and clinical symptoms to make a comprehensive judgment, and if necessary, puncture biopsy can be carried out, after a clear diagnosis, under the guidance of the clinician to carry out standardized treatment, so as to avoid delaying the condition.