Early manifestations, symmetrical multi-joint erythema, swelling and heat pain, commonly small joints of the limbs; interphalangeal proximal joints pike-shaped swelling, metacarpophalangeal (metatarsophalangeal) joints, wrists, knees, elbows, ankles, and even temporomandibular joints, as well as laryngeal cricoarytenoid joints (i.e., phalangeal joints) synovial membrane involvement. Joint stiffness in the morning and gradual reduction in the afternoon is one of the important features of the disease. Clinically, the degree of joint stiffness can often be used as an indicator to evaluate the changes in the condition and activity, the longer the morning stiffness, the more serious the condition, the disease is the situation of the owl. In the middle and late stage performance: with the development of the disease, turn into chronic, prolonged, synovial exudate develops into proliferation, granulomatous lesions, joint activity is limited, and then erosion of bone, cartilage, caused by the displacement of the joint surface and subluxation, coupled with the ligament, the joint capsule and the destruction of periarticular tissues, so that the joints are deformed. Commonly, the fingers in the metacarpophalangeal joint to (little finger) lateral subluxation, forming ulnar deviation deformity; finger proximal interphalangeal joint loss of the ability to straighten, distal interphalangeal joint hyperextension and flexion of the gooseneck deformity; serious patients with telescope-like deformity, due to the large amount of resorption of metacarpophalangeal bone end, the fingers are obviously shortened, the fingers of the skin like an organ-like wrinkles, the joints of the fingers are flaccid and unstable, and the fingers can be lengthened or shortened, which is ancient. Telescope. There is another kind of deformity called steep valley deformity, the dorsal side of the metacarpophalangeal joints are swollen, and the interosseous muscles are atrophied, when the patient clenches his fist, the dorsal side of the metacarpophalangeal joints are like peaks, and the soft tissues between the neighboring fingers are sunken like valleys. The occurrence of joint deformation is not proportional to the duration of the disease. Some patients can appear multi-joint, irreversible deformity within half a year, some patients have 5 years of disease, but the joint deformation is not as bad as the former, which is related to the various types of this disease, such as the acute type, wave type, slow relaxation type, and so on. Localization of other joints can often be accompanied by tenosynovitis near the affected joints, carpal tunnel syndrome (tenosynovitis of the flexor muscles of the wrist, so that the normal nerve is compressed in the carpal tunnel, and the muscle strength of the greater trochanter is reduced and atrophied) bursitis, popliteal cysts, etc.