Hand long blisters clinically known as blisters, accompanied by itching may be related to eczema, contact dermatitis, etc., need to be on the cause of compliance with immunosuppressants, antihistamines, hormones, etc.. 1. For chronic eczema, can be used externally levocetirizine and other antihistamines, external halometasone cream, or oral prednisone and other glucocorticoid drugs, tacrolimus ointment and other calcium-regulated phosphatase inhibitors, such as oral loratadine and other antihistamines, if necessary, treatment. 2. For contact dermatitis caused by external hydrocortisone cream or oral prednisone and other hormonal drugs, oral loratadine and other antihistamines, need to avoid contact with sensitizing substances in a timely manner. It is recommended to go to the hospital in time to see the blisters with itching on the hands, to clarify the cause of the disease, under the guidance of the doctor for standardized treatment, not blindly self-medication, so as not to delay the condition.