Skin blisters may be caused by physiological factors, pathological factors, first need to clarify the cause of the disease, through the treatment of the cause, drug therapy and other improvements. 1. Physiological factors: due to mechanical factors, such as friction of the hands or feet after exercise skin blisters, patients need to keep the local clean, dry, to avoid infection; if the blisters are too large, under the guidance of the doctor with iodine vapour to wipe the blisters and the skin around the disinfection, in sterile conditions, puncture the blisters, so that blisters out, and then disinfected with a clean gauze bandage to promote the healing of the wound. 2. Pathological factors: For example, when herpes zoster occurs, there may be unilateral clusters of blisters on the skin, and the pain is obvious, you need to carry out antiviral treatment under the guidance of the doctor, such as acyclovir, famciclovir and so on. Blisters on the skin may also be autoimmune diseases such as pemphigus and herpetic pemphigoid. It is recommended that patients with blisters go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors after a clear diagnosis.