End-of-life symptoms of Parkinson’s patients: 1. Patients lose their mobility completely and are unable to take care of themselves. 2. Speech difficulties. The ability to speak is severely affected, with difficulty in pronunciation and slowed speech. 3. Difficulty in swallowing. Patients have difficulty swallowing during meals, choking and coughing when drinking, and drooling. 4. involuntary body movements, such as anomia. 5. distorted joints in the limbs, and edema in the lower limbs, which usually disappears at night or after sleep. 6. pain in the limbs, and abnormal sensations in the limbs, such as warmth or coldness. 7. 8. Patients may have sleep disorders, manifesting as insomnia, difficulty falling asleep, frequent awakenings, and daytime sleepiness. 9. Patients may also experience weight loss and depression.