Blood pressure fluctuates throughout the day, and there is blood pressure variability and a morning peak in blood pressure. Many studies now show that 24-h ambulatory blood pressure is a better predictor of target organ damage and cardiovascular events, and have found that: the incidence of myocardial infarction is three times higher at 9 a.m. than at 9 p.m.; sudden cardiac death also peaks between 9 a.m. and 12 a.m.; the incidence of stroke is about 60% higher in the early morning; 60% of elderly people die in the early morning, and 70% to 80% of cardiovascular disease outbreaks; this risk is reduced by This risk decreases after 12:00 noon. This gives reason to believe that morning peak blood pressure may be closely related to the occurrence of cardiovascular events and may serve as an independent risk factor for cardiovascular disease. Although there is no unified standard for the definition of morning peak blood pressure, there are four ways to summarize the treatment of morning peak blood pressure: 1.Dosing before going to bed: Taking long-acting antihypertensive drugs orally before going to bed can ensure that the blood concentration of antihypertensive drugs in the next morning reaches the level of blood pressure reduction and effectively control morning peak blood pressure, but it may bring about the occurrence of nocturnal hypotension and may increase the incidence of cardiovascular and cerebrovascular events instead. 2, the next morning dosing: early morning after waking up oral short-acting antihypertensive drugs, so as to control the morning peak of blood pressure, but at this time the morning peak of blood pressure may have already appeared, corresponding to the pathophysiological changes have begun to occur, can not play a preventive role. 3.Timed release preparation (COER): After taking COER orally, short-acting drugs are released at regular intervals in the next morning and take effect rapidly to achieve the effect of controlling the morning peak of blood pressure, which is still under research, but from the perspective of suppressing morning peak blood pressure, it should be a better choice. 4, the next morning use of long-acting, stable antihypertensive drugs: choose the valley to peak ratio > 50%, and a higher antihypertensive smooth index (SI) of the long-acting antihypertensive drugs, so as to control the fluctuations of the 24h blood pressure, and effectively control the magnitude of the rise in blood pressure 18-24h after taking the drug, the current evidence-based medical evidence of such drugs are more adequate timetasartan, a number of clinical trials show that timetasartan than other ARB drugs in the control of A number of clinical trials have shown that temisartan is more effective than other ARBs in controlling the morning peak of blood pressure. The i-TECHO trial showed that compared with amlodipine, nifedipine controlled-release tablets provided better control of morning blood pressure. In addition, the Chinese Guidelines for the Prevention and Treatment of Hypertension clearly state that when choosing blood pressure-lowering drugs, preference should be given to drugs that are administered once a day and have a continuous 24-hour blood pressure-lowering effect. Therefore, the author believes that under the comprehensive consideration of various factors, in order to suppress morning peak blood pressure, long-acting antihypertensive drugs should be considered first, and drugs with a valley-to-peak ratio >0.5 and long-acting, smoothly lowering blood pressure should be selected.