Tailbone pain can be seen in acute or chronic trauma, chordoma, caudal tuberculosis, etc. If the use of painkillers is ineffective, you should actively consult a doctor for examination and choose the appropriate treatment according to the cause of the disease. 1. Trauma: trauma can lead to soft tissue injury around the tailbone, or even fracture of tailbone and local pain, when taking painkillers is ineffective, we should check whether there is any fracture in hospital in time, and if fracture occurs, we should have strict bed rest, and in serious cases, we should consider surgical treatment. 2. Chordoma: if the pain of caudal vertebra occurs due to chordoma, and the painkillers are ineffective, surgery can be considered to treat the pain, and extended resection can be performed, supplemented with radiotherapy and chemotherapy. 3. Tuberculosis of caudal vertebrae: when tuberculosis foci appear in caudal vertebrae, it can also cause caudal vertebrae pain, at this time, systemic anti-tuberculosis drugs should be used for treatment, such as isoniazid, rifampicin, streptomycin, etc., and the combined application of them can increase the efficacy of treatment. Patients with caudal spine pain have different causes, need to go to a specialized hospital for systematic examination, do not blindly take medication to prevent the condition from prolonging.