Punctate myelination dysplasia is usually caused by neurodevelopmental dysplasia of the brain, severe infections, etc. It can be treated with targeted therapy, hematopoietic stem cell transplantation, and gene therapy. 1. Neurodevelopmental dysplasia of the brain: Punctate myelination is a manifestation of abnormal myelin development. Myelin sheaths are formed in the later stages of the white matter of the brain. If the patient has neurodevelopmental dysplasia in the brain, it will have serious effects on the nervous system and lead to the emergence of pitting myelination dysplasia. 2. Severe infections: Punctate myelin dysplasia, which can also be caused by severe infections, viruses, poisoning, or autoimmune disorders, can present with symptoms such as mental retardation, epileptic symptoms, speech disorders, and limited mobility. For people with punctate myelin dysplasia, the principle of treatment mainly focuses on reducing complications, slowing down the progression of the disease, preventing infections, and controlling physical convulsive seizures. Commonly used treatments include targeted therapy, hematopoietic stem cell transplantation, and gene therapy. When there is any discomfort in your body, you should consult a doctor in time for appropriate examination and treatment under the doctor’s guidance to avoid delaying your condition.