Glutathione reductase is one of the important enzymes in the human body. The presence of high glutathione reductase may be caused by physiological reasons such as strenuous exercise, excessive alcohol consumption and other physiological reasons, or by pathological factors such as acute and chronic hepatitis, cirrhosis of the liver and liver cancer. 1. Physiological causes: When there are physiological factors such as strenuous exercise, drinking too much alcohol, or after a full meal, it may lead to a mild increase in glutathione reductase. In addition, newborns may also have physiological jaundice, which is characterized by a transient high glutathione reductase level, and can be reduced to the normal adult level in 3~6 months after birth. 2. Pathological causes: When suffering from acute and chronic hepatitis, cirrhosis, liver cancer, severe fatty liver disease, etc., it may also lead to high glutathione reductase. In addition, high glutathione reductase may also occur in those who suffer from biliary tract diseases such as bile duct stones and cholecystitis. If high glutathione reductase is detected during checkups, it is recommended to consult a doctor as soon as possible to identify the cause of the disease and treat it accordingly.