Knee playing closed mostly refers to the drug closure treatment of the knee joint, swelling at the ankle after the closure treatment, depending on the cause of the different treatment modalities. Drug closure treatment of the knee joint, mainly take lidocaine, glucocorticoids and other drugs, with pain relief, anti-inflammatory, repair damage and other effects. Conventional closed treatment generally has no obvious adverse effects, but frequent use of glucocorticoids for closed treatment may cause endocrine disruption, immunosuppression and other adverse effects. 1. Glucocorticosteroids have the function of regulating the synthesis and metabolism of sugar, fat and protein, and excessive use may lead to endocrine disruption and cause ankle edema. At this time, it is recommended to stop the drug closed treatment, ankle swelling can use diuretics, such as furosemide diuretic swelling. 2. Glucocorticosteroids have an immunosuppressive effect and are prone to cause infections. If the swelling is caused by an infection, anti-infective treatments, such as levofloxacin, are needed. In addition, the cause of ankle swelling is more, may also be related to chronic renal failure, heart failure, hypoproteinemia and other diseases, is not necessarily the drug closure treatment caused by the suggestion of timely consultation, clear cause, targeted treatment, the above drugs should also be used under the guidance of a doctor.