Rheumatoid arthritis is an autoimmune disease, the main treatment measures are non-steroidal anti-inflammatory drugs and pain relief, together with immunosuppressant treatment. Commonly used immunosuppressants include methotrexate, leflunomide, hydroxychloroquine sulfate, salazosulfapyridine, etc. In addition, biologics can also be used for treatment, which need to be based on the specific condition of the patient, together with the results of the relevant auxiliary examinations to choose the appropriate drugs. Most patients can achieve a better therapeutic effect through non-steroidal drugs with 2-3 kinds of immune agents, but there are some patients who are not very good at drug treatment, and then they can choose to use biological agents for treatment. In addition, severe rheumatoid arthritis with visceral involvement can also be considered for emergency treatment with biological agents, and attention should be paid to calcium supplementation in the course of treatment to prevent osteoporosis. Regular review of blood sedimentation, C-reactive protein, liver and kidney function is also required to evaluate the therapeutic effect of the drugs and adjust the dosage of the drugs if necessary.