Local closure of the sciatic nerve can be useful, but it must be used for the right indications in order to achieve a better therapeutic effect and to prevent the emergence of complications. The so-called local closure refers to the injection of anesthesia and anti-inflammatory drugs into areas with severe inflammation and obvious pain, in order to rapidly relieve the symptoms. For example, a common combination of drugs is lidocaine and dexamethasone. Some patients with associated lesions of the sciatic nerve, such as discogenic sciatica or sciatic nerve entrapment due to spasm of the pyriformis muscle, may consider closed treatment as described above if conventional conservative treatments have not been effective or if symptoms are particularly severe at the time of onset. This type of treatment can quickly relieve the pain at the site of the impingement and, through its anti-inflammatory effect, reduce the swelling of the tissues adjacent to the sciatic nerve, thus reducing the compression of the sciatic nerve. However, conservative treatment is still required for complete recovery. If the patient does not have the above indications, or if the treatment is overused, it may not be effective and may lead to Cushing’s syndrome, metabolic disorders, sodium retention and other adverse complications. It is recommended that patients with sciatic nerve related lesions should go to a regular medical institution and cooperate with the doctor to take proper treatment.