Prolonged absence of toilet bowel movement will lead to gastrointestinal diseases, endocrine diseases, vascular diseases and so on. 1. Gastrointestinal diseases: not going to the toilet for a long time will lead to dry stools, gastrointestinal absorption obstacles, causing constipation, hemorrhoids, and prolonged absence of defecation, easy to induce intestinal malignant changes, the emergence of gastrointestinal malignant tumors. 2. Endocrine diseases: long time without going to the toilet stool, will lead to intestinal contents absorption obstacles, and not discharged stool will secrete a variety of toxic substances, causing hormone disorders, endocrine disorders. 3. Vascular diseases: not going to the toilet for a long time, resulting in dry stool, discharge difficulties, if the patient is accompanied by lower limb thrombosis, due to forceful defecation, will lead to upward migration of thrombus, pulmonary embolism, infarction and other acute vascular diseases.