The symptoms of blepharospasm are as follows: 1. In mild cases, the blepharospasm is paroxysmal: frequent mild twitches that do not affect eye opening, often accompanied by dry eyes and photophobia in the early stages, and easily misdiagnosed as dry eye; 2. In severe cases, the twitches are obvious: so that eye opening is difficult, affecting vision, causing visual dysfunction and even causing functional blindness; 3. In late cases, the patient develops persistent eyelid closure: so that the patient cannot look straight, talk, or The patient’s skin wrinkles around the eyes and nasal roots increase significantly due to frequent blinking; the patient’s symptoms are reduced by wearing sunglasses or being in a dark room due to photophobia; most patients have a sensory track, which refers to a reduction in symptoms when touching specific areas of the patient, such as the forehead or around the eyes. Blepharospasm can be caused by a variety of factors, and patients present with involuntary contractions of the eyelids that cause uncontrollable eyelid closure and blinking. The most common form of blepharospasm is primary blepharospasm, a relatively common focal dystonia that is caused by spastic contraction of the orbicularis oculi muscle causing involuntary eyelid closure, often bilaterally, and progressively. The onset of this disease is most common in middle-aged and older adults, with more women than men, and about 2/3 of patients are women, and most onset is over 60 years of age. The etiology is unclear, and the frequency and duration of spasticity vary. Most patients have stable symptoms for 3-5 years, and about 1/3 of patients will have associated motor abnormalities such as Major’s syndrome, primary tremor, or Parkinson’s disease. Diagnosis should exclude secondary blepharospasm caused by keratoconjunctivitis, conjunctivitis, impingement, and blepharitis.