CIN, which stands for cervical intraepithelial neoplasia in medicine, is cervical intraepithelial neoplasia, which is a cervical precancerous lesion due to persistent infection with human papillomavirus (HPV). Cervical precancerous lesions include different levels of cervical intraepithelial neoplasia, usually divided into three levels (CIN I-III), which reflects the evolution of cervical cancer and its development is closely related to high-risk HPV infection. the probability of CIN I progressing to cervical cancer is 14%-40%, while the probability of CIN III progressing to cervical cancer is up to 71%-73%. So, if you have a colposcopic biopsy and are diagnosed with CIN, what should you do? CIN Ⅰ】Low grade intraepithelial neoplasia: mild atypical hyperplasia, light cell heterogeneity, uneven arrangement, but still maintain polarity, abnormal proliferation of cervical cells is limited to the lower 1/3 of the epithelial layer 【CIN Ⅱ】Moderate intraepithelial neoplasia: moderate atypical hyperplasia, obvious cell heterogeneity, disorganized arrangement, abnormal proliferation of cervical cells occupies the lower 2/3 of the epithelial layer CIN III] High grade intraepithelial neoplasia: Severe atypical hyperplasia, significant cell heterogeneity, loss of polarity, abnormal proliferation of cervical cells extending to more than the lower 2/3 of the upper epithelium. Treatment of CIN: Treatment of CIN I: 1) Colposcopy is satisfactory, cytology (TCT) reports low-grade lesions, including ASC-US, ASC-H or LSIL, and colposcopic biopsy results in CIN1, i.e., both are compatible, then treatment depends mainly on the combined symptoms. If there is a combination of bleeding after intercourse and cervical erosion, physical therapy may be indicated. If there are no symptoms and it is just a cervical problem detected by routine physical examination, it can be reviewed periodically. The timing and items for regular review are: repeat TCT every 6 or 12 months, or test for HPV. If the review is positive for HPV, or if the review is for ASC-US or more severe lesions, then colposcopy will be needed again. If HPV is negative, or if two consecutive cervical cytologies are normal, you can return to your regular cytology screening panel, which is currently every two years. 2) If colposcopy is unsatisfactory, endocervical scraping (ECC) should be done to rule out intracervical lesions. If CIN1 persists for more than 2 years, aggressive treatment is advisable, although observation can still be continued. Management of CIN II and CIN III: 1) For patients with CIN II and CIN III during pregnancy, they are usually not treated and colposcopy is recommended every 2 months and again 6-8 weeks after delivery for evaluation and management. 2) Different treatment plans are carried out according to the different conditions and different comorbid symptoms of patients with CIN II and CIN III. It is recommended that patients undergo HPV testing, which will help in the diagnosis and follow-up of CIN. 3) Cytology or HPV testing every 3-6 months after treatment, with the option of cytology or HPV testing once a year after 3 consecutive normal times, and colposcopy follow-up examinations if necessary. Finally, in the continuous development of CIN – early invasive carcinoma – invasive carcinoma, the natural evolution from cervical lesion to cancer generally takes about 5-10 years for 90% of women, which is an important and non-negligible period of time, and proper Proper treatment can interrupt this process. Patients who are found to have CIN are actually lucky, as long as they are treated and treated in time to eliminate cervical lesions, they naturally do not have to worry about cervical cancer anymore.