Hand skin hard, dry in the clinical treatment of the following diseases: first, palmoplantar keratoderma, this disease is mostly due to genetic factors, clinical treatment can choose strong glucocorticoid drugs, Hasinide ointment or fluticasone propionate cream coated, and with the mix of vitamin A ointment for external use, to promote the drug power to fully penetrate into the skin within the rash, so that the softening of the therapeutic purpose and effect; Second, hyperkeratotic tinea cruris, clinical treatment can be oral itraconazole capsule or fluconazole capsule, local application of terbinafine hydrochloride gel or cyclopiazepoxide cream mixed with boric acid zinc oxide ointment or vitamin E ointment for treatment.