Adverse reactions to the thirteen-valent pneumonia vaccine include fever, rash, and nausea, and usually occur within 24 hours of the injection. The thirteen-valent pneumonia vaccine refers to the thirteen-valent Streptococcus pneumoniae polysaccharide conjugate vaccine given to children. Since children are at high risk of contracting Streptococcus pneumoniae due to a lack of antibodies against the bacteria, the vaccine can reduce the likelihood of pneumonia in children. Some children may experience adverse reactions such as fever, rash, nausea, vomiting and diarrhea within 24 hours after vaccination, and these symptoms will generally resolve in two to three days. Some children may experience redness and swelling at the site of the vaccine injection, which usually takes three to five days to improve, and there is no need to worry too much. If children want to receive the 13-valent pneumonia vaccine, it must be carried out under the operation of the doctor, if there are adverse reactions after the vaccination and can not be relieved for a long time, should consult a doctor in time for examination and treatment.