Anti inflammatory injections in the buttocks will hurt, and the severity of the pain mainly depends on the injection technique and the irritation of the drug. The more skillful the operation of the health care personnel who implement the gluteal intramuscular injection, the more agile the movement, the less pain produced by the injection. Buttock anti-inflammatory injection pain is due to the injection needle piercing the skin into the subcutaneous, muscle, stimulation of local sensory nerves caused by the shorter the time of puncture, the slower the speed of injection, the lighter the action, the resulting pain will also be reduced. In addition, the severity of the pain is also related to the composition of the drug itself, different anti-inflammatory drug components of the local muscle irritation is different, the greater the irritation, the stronger the pain after injection. The more irritation, the stronger the pain after injection. For example, the pain is more obvious when injecting penicillin, but when injecting gentamicin intramuscularly, the pain is significantly reduced compared to the injection of penicillin. It is recommended to combine the condition, choose the anti-inflammatory drugs with little local irritation for buttock injection, properly appease the emotions before injection, divert the patient’s attention, and control the injection angle, strength, direction, and the speed of the injection fluid into the muscle, which can minimize the pain. Drugs should be applied under the guidance of a doctor.