We often encounter patients who say that a clinical specialist diagnoses a certain disease while the pathology diagnoses another disease, who do we believe? This involves the question of how to look at the pathological diagnosis versus the clinical diagnosis. First of all, any clinician’s diagnosis is only for the clinical symptoms and signs that appear in the patient and according to the statistically most probable diagnosis after the appearance of the symptoms and signs, and the accuracy is only probable for a certain patient. This is especially true nowadays when the disease is found earlier and earlier and the symptoms and signs are more and more atypical. A large amount of foreign retrospective data shows that the accuracy of the diagnosis made by clinicians through questioning and physical examination is between 50% and 60%, and the accuracy after combining imaging and laboratory tests is between 70% and 80%; while the accuracy of pathological diagnosis is between 95% and 99.8% (must be fully The current situation in China is that clinical information is not well provided to pathologists). It is self-evident who should be trusted more! Secondly, pathological diagnosis also has limitations. Pathological diagnosis can only be sent to the clinician for diagnosis of things in slices, relying on morphological changes that do not fully reflect the nature of the disease, and is the process of subjective judgment objective, there are differences, discrepancies are inevitable, there is no real gold standard for diagnosis, only infinitely close to the nature of the disease! Finally, the clinical – pathology must be closely integrated, clinical dynamic observation, take the lesion tissue immediately sent to the pathological examination, pathology carefully observed, more related auxiliary tests, clinical – pathologists often discussed together, only then can the disease effectively control!