Pathological diagnosis reports are generally divided into four categories: Class I: pathological diagnoses where the site, name, and nature are clear and largely definite. For example, small cell carcinoma, (gastric sinus) moderate chronic active superficial inflammation, HP+. Class II; cases where the name and nature are not completely certain, and there is not enough basis to determine the nature of a disease or growth as benign, junctional or malignant vague lesions, can be labeled as “consistent with …… “, “considered for ……”, “tends to be ……” “suggestive for ……”, “probable for ……”, “suspected for ……” “not excluded as ……” and other terms to make pathological diagnosis and provide clinical reference. For example, “lesion morphology is consistent with malignant fibrous histiocytoma”. Class III: The lesions shown in the examination material and sections are not sufficient to make a Class I or Class II diagnosis, and only a descriptive pathological diagnosis can be made. Category IV: Specimens that are too small, broken, improperly fixed, autolyzed, severely extruded, cauterized, dried, etc., to make a pathological diagnosis. Sent as extruded fibrous tissue with a small number of heterogeneous cells visible within, it is recommended to take another biopsy. Pathologists have an unwritten rule of saying what they see and “not seeing the rabbit without the hawk”. Although pathological diagnosis is the most reliable diagnostic indicator, sometimes the accuracy of the diagnostic report can be affected by various conditions. Such as specimens sent too little, can not be made into sections; tissue placed too long, tissue autolysis or dry; lymph nodes in the process of cutting broken; a case of specimens into two or more copies of the same can not reflect the full picture of the lesion; artificial loss of specimens sent to the examiner; poor quality of pathological production; pathologists experience limitations; the lack of diagnostic tools, etc.. For all these reasons, the limitations of pathological diagnosis, it is not accurate in all cases, and the most reliable diagnosis can not function properly at times. So it requires the clinician to pay attention to the location and amount of material taken, the tissue should be fixed in time, and consult the pathologist how to configure the fixation solution; no fixation solution should be sent in time, small tissues should be sealed and moisturized, and try not to use alcohol fixation. Lymph nodes should be cut the largest and never broken; keep the integrity of the material sent for examination; do not lose the specimen.