Mild increases in cortisol may cause hypokalemia. Cortisol decreases glomerular filtration rate and renal plasma flow from the kidneys, thereby increasing phosphate excretion, as well as increasing sodium and water absorption and potassium excretion by acting on the salt corticosteroid receptor and mimicking the effects of aldosterone. This results in loss of blood potassium, causing excessive conservation of blood sodium and the development of hypertension and hypokalemia. The main cause of increased cortisol is dysfunction of the hypothalamus and pituitary gland, or bilateral adrenal cortical hyperplasia caused by pituitary adenomas, or tumors of the adrenal glands themselves that cause overproduction of cortisol and lead to this condition. When there is a mild increase in cortisol, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, and choose a reasonable treatment plan under the doctor’s comprehensive analysis.