Clarithromycin itself tastes bitter, if you feel bitter in your mouth immediately after taking it, it may be caused by residual clarithromycin in your tongue or mouth, you can rinse your mouth with saline or pure water, which can improve a lot. If you have a bitter feeling in your mouth after taking it for a period of time, it may be because the drug is absorbed into the blood circulation in the gastrointestinal tract and reaches the oral cavity or tongue surface through secretion, resulting in a bitter mouth. You can take a piece of icing sugar or drink some honey water to neutralize the bitter taste. The bitterness of the mouth caused by Clarithromycin is a normal reaction. Patients need not be overly nervous, but should relax and make a reasonable choice according to their situation. The bitterness of the mouth can be improved or disappeared after taking the medicine for a period of time, and patients should not worry about the toxic effects of the drug. If the situation is serious, you can stop taking the medicine and observe, and the symptoms will improve.