Small blisters on the soles of the feet and itchy and peeling, should first find the cause of the disease, and then for the cause of the treatment and conditioning. Common causes are tinea pedis, foot eczema, sweating herpes, etc., in the treatment is mainly for the original cause of the application of drugs and so on. 1. Tinea pedis: If tinea pedis causes small blisters on the soles of the feet, itchy and peeling, you can be guided by the doctor to rub compound ketoconazole cream, miconazole nitrate cream and other antifungal topical drugs. If necessary, you need to follow the doctor’s advice to apply terbinafine hydrochloride tablets, itraconazole capsules and other oral antifungal drugs. 2. Foot eczema: If foot eczema leads to small blisters on the soles of the feet, itchy and peeling, you can apply mometasone furoate cream, boric acid solution and other drugs under the guidance of the doctor. At the same time with oral levocetirizine hydrochloride, loratadine and other antihistamines. 3. Sweat blisters: If the blisters on the soles of the feet are caused by sweat blisters, itchy and peeling, you can follow the doctor’s instructions for external investigation of tretinoin acetate urea cream, compound dexamethasone acetate cream and other drugs to be treated. Small blisters on the soles of the feet and itchy and peeling, avoid blindly self-abuse of drugs, should be timely medical care, clear specific triggers, under the guidance of the doctor reasonable application of drugs.