The drugs of gastric tetralogy are mainly anti-Helicobacter pylori drugs, these drugs can appear the situation of gastric distress, because this class of drugs are mainly antibiotic drugs more, such as amoxicillin, clarithromycin, metronidazole, will have some damage to the gastric mucosa, you can take these drugs after meals, after meals will reduce the damage to the mucosa, also can reduce the gastric mucosa edema, congestion, erosion, thus reducing Stomach upset. If you still do not see relief from stomach distress, you can give appropriate symptomatic treatment with drugs that protect the gastric mucosa, commonly used are Mosapride citrate capsules, as well as rehabilitation new liquid, Metzolim, etc., most of which can also play a role in relief. If you still do not see relief, you need to temporarily discontinue the quadruple therapy and wait for the mucosal damage of the stomach to recover before continuing to take it.