Ant-bite-like pain in the skin of the feet, also known as tingling discomfort, may be related to diabetic peripheral neuropathy, vitamin B1 deficiency, and sciatica. In addition to the treatment of the cause of the disease, the main medication is to give some nutritive drugs, such as methylcobalamin tablets, vitamin B1 tablets and so on. 1. Diabetic peripheral neuropathy: it is a complication of diabetes mellitus, in addition to the nutrition of the nerves, active treatment of the primary disease is the main measure to improve the neuralgia, such as metformin, acarbose and other hypoglycemic drugs to treat diabetes mellitus and so on. 2. Vitamin B1 deficiency: Vitamin B1 deficiency is also known as foot fungus, which is mainly manifested as abdominal distension, fatigue, dyspepsia, as well as abnormal sensation of both lower limbs, etc. In terms of treatment, it is mainly to give vitamin B1 deficiency directly. In terms of treatment, it is mainly given directly to vitamin B1 tablets, and can take intramuscular injection of vitamin B1 to supplement vitamin B1. 3. Sciatica: with the lumbar spine lesions caused by nerve compression related to the nutritional nerve treatment at the same time, can be combined with dehydration (mannitol, dexamethasone), anti-inflammatory analgesic (naproxen) drug therapy. Due to the complexity of the cause of the disease, the specific situation needs to be diagnosed by a doctor, and then choose the relevant drug treatment according to the individual’s physical condition.