The antihypertensive drugs of diphenhydramine class are calcium antagonist antihypertensive drugs, commonly used amlodipine benzenesulfonate, nifedipine controlled-release tablets, felodipine extended-release tablets, etc. These drugs are medium- and long-acting antihypertensive drugs, with stable and long-lasting antihypertensive effects, and can be taken for a long time as long as the blood pressure control is up to the standard and there are no side-effects. The common side effects of diphenhydramine are palpitations, headache, flushing, edema, gingival hyperplasia, etc. If these side effects do not occur, and the blood pressure control is stable after oral intake of these drugs and the blood pressure reaches the standard, it is recommended to take them for a long time to ensure that the blood pressure is stable. If these side effects occur, especially affecting the life of patients can not tolerate, you can change the type of antihypertensive drugs, there are angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists and other antihypertensive drugs can be chosen. Whether the use of antihypertensive drugs, long-term use, or need to be replaced, it is recommended to consult the cardiology department in a timely manner, by the guidance of a professional doctor to adjust.