Patients with advanced bronchial cancer may have local and systemic symptoms such as cough, shortness of breath, bloody sputum; superior vena cava obstruction syndrome, hoarseness, headache and other symptoms related to tumor invasion and metastasis. 1. Local and systemic symptoms: local and systemic symptoms that may be caused by cancer cells include cough, blood in sputum, chest tightness and chest pain, shortness of breath, loss of appetite, weight loss and so on. 2. Symptoms of cancer cell invasion and metastasis: patients may suffer from superior vena cava obstruction syndrome, horner syndrome, hoarseness when cancer cells invade the recurrent laryngeal nerve, brain metastasis of cancer cells may cause headache, vomiting, hemiplegia, etc. Bone metastasis may cause patients to suffer from continuous pain in the corresponding parts. Patients with advanced stage should consult hospitals in time and take corresponding treatment measures under the guidance of professional doctors to control the disease process, prolong the survival time and improve the quality of life.