Metronidazole treatment for toothache is still relatively effective, but it also depends on the cause of toothache, and the treatment method should be chosen according to the specific cause of toothache, so as to completely solve the problem. 1, pulpitis, periapical inflammation: pulpitis and periapical inflammation are generally progressed from caries, the main symptom is pain, general anti-inflammatory drugs can be used roxithromycin and metronidazole. However, the simple medicine cannot solve the big problem, the best treatment is to do root canal treatment. 2, periodontal abscess: for the pain caused by periodontal abscess, metronidazole is useful, but also with local scraping and rinsing, so as to completely solve the pain caused by periodontal abscess. 3, wisdom tooth pericoronitis: wisdom tooth pericoronitis is an inflammation of the surrounding soft tissues caused by the blocked wisdom tooth, which will have very obvious symptoms of swelling and pain. In addition to anti-inflammatory treatment with oral medications such as metronidazole, local irrigation treatment is also done. When the swelling and pain of pericoronitis are eliminated, the wisdom tooth should be extracted in time, otherwise the pericoronitis will recur. The toothache needs to be thoroughly treated accordingly. Although drugs such as metronidazole can relieve the symptoms for a while, they do not treat the symptoms and will not completely solve the toothache problem.