Positive fecal occult blood is recommended to choose the treatment of drugs and surgery. Those who are positive for Helicobacter pylori are recommended to choose quadruple therapy treatment, i.e. one proton pump inhibitor, one bismuth agent and two antibiotics. 1. Positive fecal occult blood (1) Drug treatment: positive fecal occult blood indicates the presence of gastrointestinal bleeding, it is recommended to take drugs to inhibit gastric acid secretion, protect gastric mucosa and stop bleeding, such as: omeprazole, bismuth potassium citrate, Yunnan Baiyao and so on. (2) Surgical treatment: if the occult blood in stool is caused by gastric cancer, gastric polyp, colon cancer, rectal cancer, intestinal polyp and other gastrointestinal tumors. Timely surgical treatment is recommended. However, for patients with malignant tumors, in addition to surgical treatment, they also need to cooperate with chemotherapy, radiotherapy, targeted drug therapy, etc., to inhibit the spreading and recurrence of cancer cells. 2. When Helicobacter pylori is positive and needs to be treated, it is recommended to use one proton pump inhibitor, one bismuth agent and two antibiotics, i.e. quadruple therapy. (1) Proton pump inhibitor: including rabeprazole, omeprazole, etc., which can inhibit and reduce the secretion of gastric acid. (2) Bismuth: including bismuth potassium citrate, bismuth pectin, etc., which is more effective in improving symptoms such as stomach pain and heartburn. (3) Antibiotics: including metronidazole, amoxicillin, clarithromycin, etc. The treatment with antibiotic drugs requires the combined use of two antibiotics. The appearance of blood positive stool, Helicobacter pylori positive, it is recommended to go to the hospital in a timely manner, after the doctor’s interview, combined with the patient’s own condition and cause of the disease, to develop the appropriate treatment program, and then follow the doctor’s instructions for treatment.