Taking omeprazole mouth is still sour, can be improved through the improvement of living habits and diet, the treatment of the cause and other methods. Sour mouth is considered excessive secretion of gastric acid, usually seen in gastroesophageal reflux, acute and chronic gastritis, peptic ulcer and other diseases. 1. Improve living habits and eating habits: usually in the diet should avoid spicy and greasy, barbecue fried food, try to light and easy to digest food, while eating regularly, regular and quantitative, chewing and swallowing, to avoid overeating, the patient needs to quit smoking and alcohol to avoid the impact of bad habits. 2. Treatment of the cause: patients due to gastroesophageal reflux caused by, in addition to the application of omeprazole, can be used with the application of aluminum phosphate gel and other drugs, the condition is more serious, by the physician weighing the pros and cons of laparoscopic fundoplication and endoscopic anti-reflux surgery; due to acute and chronic gastritis, peptic ulcer combined with the bacterium Helicobacter pylori infection caused by the application of amoxicillin capsules, clarithromycin and other antimicrobial drugs to treatment. Patients need to go to the regular hospital, the physician according to the condition of the appropriate treatment, follow the doctor’s instructions.