Thickening of the lower esophageal wall is caused by inflammatory, occupying lesions in the esophageal area. When food enters the stomach, the esophagus expels food into the stomach by peristalsis. In the process of peristalsis, temporary thickening occurs due to sphincter contraction, which is often not accompanied by discomfort in the esophagus and is a normal phenomenon. In some people, the thickening of the lower esophageal wall is caused by inflammation, such as esophagitis. During an attack of esophagitis, there is congestion and edema in the mucosa of the esophagus, which not only leads to relative narrowing of the lumen, but also thickening of the wall of the tube. When abnormal hyperplasia occurs in the esophagus, the hyperplasia will invade the smooth muscle of the esophagus and cause thickening of the wall of the lower esophagus, which is commonly seen in esophageal cancer. Once esophageal cancer occurs, it will not only have wall thickening, but also have symptoms such as difficulty in swallowing and hoarse voice.